详情描述
RBC8 is a RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). RBC8 suppresses growth of xenograft tumors in mice. e Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics.
Product information
CAS Number: 361185-42-4
Molecular Weight: 424.45
Formula: C25H20N4O3
Chemical Name: 6-amino-4-(2, 5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1H, 4H-pyrano[2, 3-c]pyrazole-5-carbonitrile
Smiles: COC1=CC=C(C=C1C1C(C#N)=C(N)OC2=NNC(=C21)C1=CC2=CC=CC=C2C=C1)OC
InChiKey: CLMQBVUFKIKYLU-UHFFFAOYSA-N
InChi: InChI=1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.