Cot inhibitor-1

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM.

Product information

CAS Number: 915365-57-0

Molecular Weight: 553.46

Formula: C27H27Cl2FN8

Chemical Name: 6-[({1-[2-(azepan-1-yl)ethyl]-1H-1,2,3-triazol-4-yl}methyl)amino]-8-chloro-4-[(3-chloro-4-fluorophenyl)amino]quinoline-3-carbonitrile

Smiles: N#CC1C=NC2=C(C=C(C=C2Cl)NCC2=CN(CCN3CCCCCC3)N=N2)C=1NC1=CC(Cl)=C(F)C=C1

InChiKey: ZWFKJFUFYPOTKL-UHFFFAOYSA-N

InChi: InChI=1S/C27H27Cl2FN8/c28-23-12-19(5-6-25(23)30)34-26-18(14-31)15-33-27-22(26)11-20(13-24(27)29)32-16-21-17-38(36-35-21)10-9-37-7-3-1-2-4-8-37/h5-6,11-13,15,17,32H,1-4,7-10,16H2,(H,33,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.