NB-598 Hydrochloride


Catalog No. Size 价格库存数量
S1693-2 Solid 2 mg ¥115
S1693-10 Solid 10 mg ¥345


NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly.

Product information

CAS Number: 136719-25-0

Molecular Weight: 486.13

Formula: C27H32ClNOS2

Chemical Name: {[3-({[3,3'-bithiophen]-5-yl}methoxy)phenyl]methyl}[(2E)-6,6-dimethylhept-2-en-4-yn-1-yl]ethylamine hydrochloride

Smiles: Cl.CCN(C/C=C/C#CC(C)(C)C)CC1=CC(=CC=C1)OCC1=CC(=CS1)C1=CSC=C1


InChi: InChI=1S/C27H31NOS2.ClH/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23;/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3;1H/b8-6+;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.


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