详情描述
Ko-143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Ko-143 is a nontoxic analog of fungal toxin fumitremorgin C, is a potent inhibitor of ABCG2.
Product information
CAS Number: 461054-93-3
Molecular Weight: 469.57
Formula: C26H35N3O5
Chemical Name: tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11(16),12,14-tetraen-5-yl]propanoate
Smiles: CC(C)C[C@H]1C2NC3=CC(=CC=C3C=2C[C@H]2C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)N21)OC
InChiKey: NXNRAECHCJZNRF-JBACZVJFSA-N
InChi: InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.