Catalog No. Size 价格库存数量
S1967-2 Solid 2 mg ¥100
售罄
不可用
S1967-10 Solid 10 mg ¥300
售罄
不可用

详情描述

SPS-4251, also known as AS-77 and PAP-1, is a KCNA3 (Potassium voltage-gated channel, shaker-related subfamily, member 3) channel blocker potentially for the treatment of plaque psoriasis. Kv1.3 channels regulate the activation/proliferation of effector memory T cells and thus play a critical role in the pathogenesis of autoimmune diseases. PAP-1 reduced the secretion of TNFα by adipose tissue but had no effect on the secretion of IL-6. PAP-1 can also potentially inhibit the exocytosis of cytoplasmic granules from CD4(+)CD28(null) T cells.

Product information

CAS Number: 870653-45-5

Molecular Weight: 350.36

Formula: C21H18O5

Chemical Name: 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one

Smiles: O=C1C=CC2C(OCCCCOC3C=CC=CC=3)=C3C=COC3=CC=2O1

InChiKey: KINMYBBFQRSVLL-UHFFFAOYSA-N

InChi: InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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