Catalog No. Size 价格库存数量
S1979-2 Solid 2 mg ¥135
S1979-10 Solid 10 mg ¥405


ONO-AE3-208 is a potent n EP4 antagonist (Ki = 1.3 nM). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. The in vitro cell invasion and migration were suppressed by ONO-AE3-208 in a dose-dependent manner without affecting cell proliferation. The in vivo bone metastasis of PC3 was also suppressed by ONO-AE3-208 treatment. EP4 expression levels were correlated with prostate cancer cell invasiveness and EP4 specific antagonist ONO-AE3-208 suppressed cell invasion, migration, and bone metastasis, indicating that it is a potential novel therapeutic modality for the treatment of metastatic prostate cancer.

Product information

CAS Number: 402473-54-5

Molecular Weight: 404.43

Formula: C24H21FN2O3

Chemical Name: 4-{4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanamido]phenyl}butanoic acid

Smiles: CC(C1=CC=C(F)C2=CC=CC=C21)C(=O)NC1=CC(=CC=C1CCCC(O)=O)C#N


InChi: InChI=1S/C24H21FN2O3/c1-15(18-11-12-21(25)20-7-3-2-6-19(18)20)24(30)27-22-13-16(14-26)9-10-17(22)5-4-8-23(28)29/h2-3,6-7,9-13,15H,4-5,8H2,1H3,(H,27,30)(H,28,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.


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