详情描述
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. RI-1 holds promise as an oncologic drug. Furthermore, RI-1 represents a unique tool to dissect the network of reaction pathways that contribute to DNA repair in cells.
Product information
CAS Number: 415713-60-9
Molecular Weight: 361.61
Formula: C14H11Cl3N2O3
Chemical Name: 3-chloro-1-(3,4-dichlorophenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Smiles: O=C1C(Cl)=C(C(=O)N1C1C=C(Cl)C(Cl)=CC=1)N1CCOCC1
InChiKey: MWSUIZKGNWELRF-UHFFFAOYSA-N
InChi: InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.