Porfimer Sodium

Porfimer sodium is t he sodium salt of a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units with photodynamic activity. Absorbed selectively by tumor cells, porfimer produces oxygen radicals after activation by 630 nm wavelength laser light, resulting in tumor cell cytotoxicity. In addition, tumor cell death may occur due to ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by the release of thromboxane A2.

Product information

CAS Number: 97067-70-4

Molecular Weight: 1179.36

Formula: C68H74N8O11

Synonym:

Dihematoporphyrin Ether

Photofrin

Chemical Name: 3-[9-(1-{1-[10, 14-bis(2-carboxyethyl)-19-(1-hydroxyethyl)-5, 9, 15, 20-tetramethyl-21, 22, 23, 24-tetraazapentacyclo[16.2.1.1, .1, .1, ]tetracosa-1, 3, 5, 7, 9, 11(23), 12, 14, 16, 18(21), 19-undecaen-4-yl]ethoxy}ethyl)-20-(2-carboxyethyl)-14-(1-hydroxyethyl)-5, 10, 15, 19-tetramethyl-21, 22, 23, 24-tetraazapentacyclo[16.2.1.1, .1, .1, ]tetracosa-1(21), 2, 4, 6, 8(23), 9, 11, 13, 15, 17, 19-undecaen-4-yl]propanoic acid

Smiles: CC1=C(C(C)O)C2=CC3=NC(=CC4NC(C=C5N=C(C=C1N2)C(C)=C5CCC(O)=O)=C(CCC(O)=O)C=4C)C(C(C)OC(C)C1C2=CC4=NC(=CC5NC(C=C6N=C(C=C(N2)C=1C)C(C)=C6CCC(O)=O)=C(CCC(O)=O)C=5C)C(C(C)O)=C4C)=C3C

InChiKey: VAYJWFGRGMQINH-STKOUIOXSA-N

InChi: InChI=1S/C68H74N8O11/c1-29-41(13-17-61(79)80)53-28-56-44(16-20-64(85)86)32(4)48(72-56)24-59-68(36(8)52(76-59)25-58-65(37(9)77)33(5)49(73-58)21-45(29)69-53)40(12)87-39(11)67-35(7)50-22-46-30(2)42(14-18-62(81)82)54(70-46)27-55-43(15-19-63(83)84)31(3)47(71-55)23-57-66(38(10)78)34(6)51(74-57)26-60(67)75-50/h21-28,37-40,71-73,75,77-78H,13-20H2,1-12H3,(H,79,80)(H,81,82)(H,83,84)(H,85,86)/b45-21-,46-22-,47-23-,48-24-,49-21-,50-22-,51-26-,52-25-,53-28-,54-27-,55-27-,56-28-,57-23-,58-25-,59-24-,60-26-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Pereira SP, Ayaru L, Ackroyd R, Mitton D, Fullarton G, Zammit M, Grzebieniak Z, Messmann H, Ortner MA, Gao L, Trinh MM, Spénard J. The pharmacokinetics and safety of porfimer after repeated administration 30-45 days apart to patients undergoing photodynamic therapy. Aliment Pharmacol Ther. 2010 Sep;32(6):821-7.
2. Yumita N, Han QS, Umemura S. Sonodynamically induced apoptosis with porfimer sodium in HL-60 cells. Anticancer Drugs. 2007 Nov;18(10):1149-56.
3. Mino-Kenudson M, Ban S, Ohana M, Puricelli W, Deshpande V, Shimizu M, Nishioka NS, Lauwers GY. Buried dysplasia and early adenocarcinoma arising in barrett esophagus after porfimer-photodynamic therapy. Am J Surg Pathol. 2007 Mar;31(3):403-9.

Products are for research use only. Not for human use.