20-HETE

20-HETE is a lipid mediator which activates the transcription of ACE via NFkB translocation and promoter binding. This causes detrimental effects in cerebral circulation, and modulating KCa3.1 channels.

Product information

CAS Number: 79551-86-3

Molecular Weight: 320.47

Formula: C20H32O3

Synonym:

20-hydroxy Arachidonic Acid

Chemical Name: (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid

Smiles: OCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O

InChiKey: NNDIXBJHNLFJJP-DTLRTWKJSA-N

InChi: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Rocic P, Schwartzman ML. 20-HETE in the regulation of vascular and cardiac function. Pharmacol Ther. 2018 Jul 23. pii: S0163-7258(18)30123-2.
2. Lu L, Wang M, Wei X, Li W. 20-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. Front Aging Neurosci. 2018 Jul 16;10:207.

Products are for research use only. Not for human use.