Tenovin 6 Hydrochloride

Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Tnv-6 causes non-genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to Tnv-6 did not induce cellular apoptosis or p53-pathway activity. Transcriptomic profiling identified a gene program influenced by Tnv-6 that included autophagy-lysosomal pathway genes.

Product information

CAS Number: 1011301-29-3

Molecular Weight: 491.09

Formula: C25H35ClN4O2S

Synonym:

Tenovin 6 hydrochloride

Tenovin6 hydrochloride

Tenovin 2

Chemical Name: N-[4-({[(4-tert-butylphenyl)formamido]methanethioyl}amino)phenyl]-5-(dimethylamino)pentanamide hydrochloride

Smiles: Cl.CN(C)CCCCC(=O)NC1C=CC(=CC=1)NC(=S)NC(=O)C1C=CC(=CC=1)C(C)(C)C

InChiKey: UBNCTIDXQDCEPI-UHFFFAOYSA-N

InChi: InChI=1S/C25H34N4O2S.ClH/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5;/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.