p53 and MDM2 proteins-interaction-inhibitor dihydrochloride

p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.

Product information

CAS Number: 2070009-27-5

Molecular Weight: 807.68

Formula: C40H51Cl4N5O4

Chemical Name: 2-{4-[(4S, 5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4, 5-bis(4-chlorophenyl)-4, 5-dimethyl-4, 5-dihydro-1H-imidazole-1-carbonyl]piperazin-1-yl}-1-(morpholin-4-yl)ethan-1-one dihydrochloride

Smiles: Cl.Cl.CC(C)(C)C1=CC(OCC)=C(C=C1)C1=N[C@@](C)(C2C=CC(Cl)=CC=2)[C@@](C)(C2C=CC(Cl)=CC=2)N1C(=O)N1CCN(CC(=O)N2CCOCC2)CC1

InChiKey: LSDSITOZGWIHGA-IBBBAUQKSA-N

InChi: InChI=1S/C40H49Cl2N5O4.2ClH/c1-7-51-34-26-30(38(2,3)4)12-17-33(34)36-43-39(5,28-8-13-31(41)14-9-28)40(6,29-10-15-32(42)16-11-29)47(36)37(49)46-20-18-44(19-21-46)27-35(48)45-22-24-50-25-23-45;;/h8-17,26H,7,18-25,27H2,1-6H3;2*1H/t39-,40+;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Chen R, et al. A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors. Biochemistry. 2017 Jun 27;56(25):3273-3282.

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