详情描述
XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
Product information
CAS Number: 1515856-92-4
Molecular Weight: 366.33
Formula: C18H17F3N2O3
Synonym:
XEN 445
XEN-445
Chemical Name: 2-[(3S)-3-[(pyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
Smiles: OC(=O)C1=CC(=CC=C1N1C[C@H](CC1)OCC1=CC=CC=N1)C(F)(F)F
InChiKey: NBGRERFNOKZQLO-AWEZNQCLSA-N
InChi: InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.