PF-8380 Hydrochloride

PF-8380 is a potent autotaxin inhibitor with an IC(50) of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

Product information

CAS Number: 2070015-01-7

Molecular Weight: 514.79

Formula: C22H22Cl3N3O5

Synonym:

PF 8380 hydrochloride

PF8380 hydrochloride

Chemical Name: (3, 5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2, 3-dihydro-1, 3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate hydrochloride

Smiles: Cl.O=C(OCC1C=C(Cl)C=C(Cl)C=1)N1CCN(CCC(=O)C2=CC3OC(=O)NC=3C=C2)CC1

InChiKey: OEPBHEIJCGMALL-UHFFFAOYSA-N

InChi: InChI=1S/C22H21Cl2N3O5.ClH/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18;/h1-2,9-12H,3-8,13H2,(H,25,29);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Szepanowski F, Derksen A, Steiner I, Meyer Zu Hörste G, Daldrup T, Hartung HP, Kieseier BC. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. J Neuroinflammation. 2016 Jun 10;13(1):143.
2. Velasco M, O'Sullivan C, Sheridan GK. Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain. Neuropharmacology. 2016 Apr 5. pii: S0028-3908(16)30129-0.
3. Katsifa A, Kaffe E, Nikolaidou-Katsaridou N, Economides AN, Newbigging S, McKerlie C, Aidinis V. The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. PLoS One. 2015 Nov 16;10(11):e0143083.

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