详情描述
PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder.
Product information
CAS Number: 2089205-64-9
Molecular Weight: 889.00
Formula: C43H48N6O11S2
Chemical Name: 14-({4-[(1, 3-benzothiazol-5-yl)amino]-6-(2-methylpropane-2-sulfonyl)quinolin-7-yl}oxy)-N-[2-(2, 6-dioxopiperidin-3-yl)-1-oxo-2, 3-dihydro-1H-isoindol-4-yl]-3, 6, 9, 12-tetraoxatetradecanamide
Smiles: CC(C)(C)S(=O)(=O)C1=CC2C(C=C1OCCOCCOCCOCCOCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)=NC=CC=2NC1C=C2N=CSC2=CC=1
InChiKey: BRZGXSNAXRPPFI-UHFFFAOYSA-N
InChi: InChI=1S/C43H48N6O11S2/c1-43(2,3)62(54,55)38-22-29-32(46-27-7-9-37-34(21-27)45-26-61-37)11-12-44-33(29)23-36(38)60-20-19-58-16-15-56-13-14-57-17-18-59-25-40(51)47-31-6-4-5-28-30(31)24-49(42(28)53)35-8-10-39(50)48-41(35)52/h4-7,9,11-12,21-23,26,35H,8,10,13-20,24-25H2,1-3H3,(H,44,46)(H,47,51)(H,48,50,52)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (112.49 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation
References:
- John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.
Products are for research use only. Not for human use.