PROTAC BRD9 Degrader-1

PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology.

Product information

CAS Number: 2097971-01-0

Molecular Weight: 903.98

Formula: C42H45N7O12S2

Chemical Name: 2-(4-{2-[N-(1, 1-dioxo-1-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4H, 5H-thieno[3, 2-c]pyridin-7-yl}-2-methoxyphenoxy)-N-[4-(2-{[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]oxy}acetamido)butyl]acetamide

Smiles: CN1C=C(C2SC(=CC=2C1=O)C(=N)NC1CCS(=O)(=O)CC1)C1=CC(OC)=C(C=C1)OCC(=O)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

InChiKey: LOLHUPGCPDURJG-UHFFFAOYSA-N

InChi: InChI=1S/C42H45N7O12S2/c1-48-20-27(37-26(40(48)54)19-32(62-37)38(43)46-24-12-16-63(57,58)17-13-24)23-8-10-29(31(18-23)59-2)60-21-34(51)44-14-3-4-15-45-35(52)22-61-30-7-5-6-25-36(30)42(56)49(41(25)55)28-9-11-33(50)47-39(28)53/h5-8,10,18-20,24,28H,3-4,9,11-17,21-22H2,1-2H3,(H2,43,46)(H,44,51)(H,45,52)(H,47,50,53)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 150 mg/mL (165.93 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.

Products are for research use only. Not for human use.