TAK-875

TAK-875, is a potent, selective, and orally bioavailable GPR40 agonist, with a pharmacokinetic profile enabling long-acting drug efficacy. TAK-875 showed potent plasma glucose-lowering action and insulinotropic action during an oral glucose tolerance test in female Wistar fatty rats with impaired glucose tolerance. TAK-875 is currently in clinical trials for the treatment of type 2 diabetes mellitus.

Product information

CAS Number: 1000413-72-8

Molecular Weight: 524.63

Formula: C29H32O7S

Synonym:

Fasiglifam

Chemical Name: (S)-2-(6-((2', 6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1, 1'-biphenyl]-3-yl)methoxy)-2, 3-dihydrobenzofuran-3-yl)acetic acid

Smiles: CC1C=C(C=C(C)C=1C1=CC(COC2=CC3OC[C@@H](CC(O)=O)C=3C=C2)=CC=C1)OCCCS(C)(=O)=O

InChiKey: BZCALJIHZVNMGJ-HSZRJFAPSA-N

InChi: InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.