详情描述
PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.
Product information
CAS Number: 908115-27-5
Molecular Weight: 521.53
Formula: C25H30F3N5O4
Synonym:
PF-4929113
SNX-5422
Related CAS Number:
1173111-67-5 (PF-04929113 mesylate)
Chemical Name: (1r, 4r)-4-((2-carbamoyl-5-(6, 6-dimethyl-4-oxo-3-(trifluoromethyl)-4, 5, 6, 7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate
Smiles: CC1(C)CC(=O)C2C(=NN(C3=CC(N[C@@H]4CC[C@H](CC4)OC(=O)CN)=C(C=C3)C(N)=O)C=2C1)C(F)(F)F
InChiKey: AVDSOVJPJZVBTC-CTYIDZIISA-N
InChi: InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)/t13-,15-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.