详情描述
PF-562271, also known as PF-562, 271 and PF-271, is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF-562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival.
Product information
CAS Number: 717907-75-0
Molecular Weight: 507.49
Formula: C21H20F3N7O3S
Synonym:
PF-562271
PF562271 free base
PF-271
PF-562, 271
Related CAS Number:
939791-38-5 (PF-562271 Besylate)
939791-41-0 (PF-562271 HCl)
939791-39-6 (PF-562271 mesylate)
939791-40-9 (PF-562271 tosylate)
Chemical Name: N-methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide
Smiles: CN(C1=NC=CC=C1CNC1=NC(NC2=CC3CC(=O)NC=3C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O
InChiKey: MZDKLVOWGIOKTN-UHFFFAOYSA-N
InChi: InChI=1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.