详情描述
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
Product information
CAS Number: 480-18-2
Molecular Weight: 304.25
Formula: C15H12O7
Synonym:
Taxifoliol
Lariksin
Lavitol
Catechin hydrate
Dihydroquercetin
Chemical Name: (2R, 3R)-2-(3, 4-dihydroxyphenyl)-3, 5, 7-trihydroxy-3, 4-dihydro-2H-1-benzopyran-4-one
Smiles: O[C@@H]1[C@H](OC2=CC(O)=CC(O)=C2C1=O)C1=CC(O)=C(O)C=C1
InChiKey: CXQWRCVTCMQVQX-LSDHHAIUSA-N
InChi: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 60 mg/mL(197.2 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Taxifolin is not mutagenic and low toxic compared to Qercetin. It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner.
References:
- Luo H, et al. Nutr Cancer, 2008, 60(6), 800-809.
- Lee SB, et al. Biol Pharm Bull, 2007, 30(6), 1074-1079.
- Makena PS, et al. Environ Mol Mutagen, 2009, 50(6), 451-459.
Products are for research use only. Not for human use.