详情描述
ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
Product information
CAS Number: 2254001-81-3
Molecular Weight: 428.43
Formula: C23H22F2N2O4
Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid
Smiles: CC1C=C(C=C(C=1)OC1=NC(O[C@H](CC)C(O)=O)=C(F)C=C1F)C1=CC(CN)=CC=C1
InChiKey: CVNXUNVHFJANHX-HXUWFJFHSA-N
InChi: InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 86 mg/mL (207.53 mM) Ethanol 86 mg/mL (207.53 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Imadul Islam, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3
Products are for research use only. Not for human use.