STAT3-IN-1

STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.

Product information

CAS Number: 2059952-75-7

Molecular Weight: 475.53

Formula: C28H29NO6

Chemical Name: (E)-N-(4-((E)-3,5-dimethoxystyryl)phenyl)-3-(3,4,5-trimethoxyphenyl)acrylamide

Smiles: COC1=CC(=CC(=C1)OC)/C=C/C1C=CC(=CC=1)NC(=O)/C=C/C1=CC(OC)=C(OC)C(=C1)OC

InChiKey: KOZAEBHIXYBHKA-FCXQYMQBSA-N

InChi: InChI=1S/C28H29NO6/c1-31-23-14-20(15-24(18-23)32-2)7-6-19-8-11-22(12-9-19)29-27(30)13-10-21-16-25(33-3)28(35-5)26(17-21)34-4/h6-18H,1-5H3,(H,29,30)/b7-6+,13-10+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 95 mg/mL(199.77 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Shanshan Li, et al. Eur J Med Chem. 2016 Nov 29;124:1006-1018.

Products are for research use only. Not for human use.