TA-01

TA-01 is an inducer of cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction.

Product information

CAS Number: 1784751-18-3

Molecular Weight: 351.32

Formula: C20H12F3N3

Synonym:

TA-01

TA 01

TA01

Chemical Name: 4-(2-(2,6-difluorophenyl)-4-(2-fluorophenyl)-1H-imidazol-5-yl)pyridine

Smiles: FC1C=CC=C(F)C=1C1NC(=C(N=1)C1=CC=CC=C1F)C1C=CN=CC=1

InChiKey: QUGPSRHANXSBSL-UHFFFAOYSA-N

InChi: InChI=1S/C20H12F3N3/c21-14-5-2-1-4-13(14)19-18(12-8-10-24-11-9-12)25-20(26-19)17-15(22)6-3-7-16(17)23/h1-11H,(H,25,26)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration.

References:

1. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.

Products are for research use only. Not for human use.