DB07268

DB07268 is a potent and selective JNK1 inhibitor.

Product information

CAS Number: 929007-72-7

Molecular Weight: 321.33

Formula: C17H15N5O2

Synonym:

DB-07268

DB 07268

DB07268

Chemical Name: 2-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)amino)benzamide

Smiles: NC(=O)C1=CC=CC=C1NC1=CC=NC(NC2=CC(O)=CC=C2)=N1

InChiKey: QHPKKGUGRGRSGA-UHFFFAOYSA-N

InChi: InChI=1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 32 mg/mL (99.59 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively.

References:

1. Liu M, et al. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72.

Products are for research use only. Not for human use.