RU-SKI 43, Hhat Inhibitor

RU-SKI 43 is an inhibitor of Hedgehog acyltransferase (Hhat). It blocks Sonic hedgehog (Shh) signaling.

Product information

CAS Number: 1043797-53-0

Molecular Weight: 386.55

Formula: C22H30N2O2S

Chemical Name: 2-[(2-methylbutyl)amino]-1-{4-[(3-methylphenoxy)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}ethan-1-one

Smiles: CC1C=CC=C(C=1)OCC1C2C=CSC=2CCN1C(=O)CNCC(C)CC

InChiKey: AEENEMOEBJOKGN-UHFFFAOYSA-N

InChi: InChI=1S/C22H30N2O2S/c1-4-16(2)13-23-14-22(25)24-10-8-21-19(9-11-27-21)20(24)15-26-18-7-5-6-17(3)12-18/h5-7,9,11-12,16,20,23H,4,8,10,13-15H2,1-3H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

RU-SKI 43 was used at 10-20 µM final concentration in vitro and in cellular assays.

References:

1. Petrova E, et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. (2013) Nat Chem Biol. 9(4):247-9.
2. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. (2014) Oncogene. In press.

Products are for research use only. Not for human use.