UM729, AhR antagonists

UM729 is an enhancer of AhR antagonists. UM-729 enhances the self-renewal of human hematopoietic stem cells in vitro. UM729 does not inhibit the aryl hydrocarbon receptor (AhR) pathway, but has been shown to collaborate with AHR antagonists in preventing differentiation of acute myeloid leukemia (AML) cells in culture. UM729 was originally discovered in a screen of compounds capable of promoting human CD34+ cell expansion. UM-729 may be used for the enhancement of human HSC self-renewal in culture, and for the maintenance of human leukemia stem cell (LSC) activity in culture.

Product information

CAS Number: 1448723-60-1

Molecular Weight: 367.44

Formula: C20H25N5O2

Synonym:

UM 729

UM-729

Chemical Name: methyl 4-{[3-(piperidin-1-yl)propyl]amino}-9H-pyrimido[4,5-b]indole-7-carboxylate

Smiles: COC(=O)C1=CC2NC3=NC=NC(NCCCN4CCCCC4)=C3C=2C=C1

InChiKey: SIBCJMZHJZDUNK-UHFFFAOYSA-N

InChi: InChI=1S/C20H25N5O2/c1-27-20(26)14-6-7-15-16(12-14)24-19-17(15)18(22-13-23-19)21-8-5-11-25-9-3-2-4-10-25/h6-7,12-13H,2-5,8-11H2,1H3,(H2,21,22,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G. Identification of 小分子化合物，新品 that support human leukemia stem cell activity ex vivo. Nat Methods. 2014 Apr;11(4):436-42.

Products are for research use only. Not for human use.