详情描述
Poloxime is a non-ATP-competitive Plk1 inhibitor. It acts by bocking pSer/pThr recognition.
Product information
CAS Number: 17302-61-3
Molecular Weight: 179.22
Formula: C10H13NO2
Synonym:
2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)-, 1-oxime
Chemical Name: 5-methyl-4-nitroso-2-(propan-2-yl)phenol
Smiles: CC1=CC(O)=C(C=C1N=O)C(C)C
InChiKey: YQVCMSSJMLGWAM-UHFFFAOYSA-N
InChi: InChI=1S/C10H13NO2/c1-6(2)8-5-9(11-13)7(3)4-10(8)12/h4-6,12H,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 100 mg/mL (557.97 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Poloxime (100 μM) inhibits phosphopeptide binding to polo-box domain (PBD) of polo-like kinase 1 (Plk1).
References:
- Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4.
- Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.
Products are for research use only. Not for human use.