nor-NOHA acetate

nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism.

Product information

CAS Number: 1140844-63-8

Molecular Weight: 296.28

Formula: C9H20N4O7

Chemical Name: (2S)-2-amino-4-(N'-hydroxycarbamimidamido)butanoic acid; bis(acetic acid)

Smiles: CC(O)=O.CC(O)=O.N[C@@H](CCNC(=N)NO)C(O)=O

InChiKey: PQFYTZJPYBMTCT-QTNFYWBSSA-N

InChi: InChI=1S/C5H12N4O3.2C2H4O2/c6-3(4(10)11)1-2-8-5(7)9-12;2*1-2(3)4/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);2*1H3,(H,3,4)/t3-;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Havlínová Z, Hroch M, Nagy A, Sišpera L, Holeček M, Chládek J. Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats. Gen Physiol Biophys. 2014;33(2):189-98. doi: 10.4149/gpb_2013078. Epub 2013 Oct 31. PubMed PMID: 24177023.
2. Hu H, Moon J, Chung JH, Kim OY, Yu R, Shin MJ. Arginase inhibition ameliorates adipose tissue inflammation in mice with diet-induced obesity. Biochem Biophys Res Commun. 2015 Aug 28;464(3):840-7. doi: 10.1016/j.bbrc.2015.07.048. Epub 2015 Jul 16. PubMed PMID: 26188090.
3. Li X, Zhu F, He Y, Luo F. [Arginase inhibitor nor-NOHA induces apoptosis and inhibits invasion and migration of HepG2 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Apr;33(4):477-482. Chinese. PubMed PMID: 28395717.

Products are for research use only. Not for human use.