PAO-Nap

PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.

Product information

CAS Number: 1613402-20-2

Molecular Weight: 509.39

Formula: C24H24AsN3O5

Chemical Name: [4-(6-{8-amino-2, 4-dioxo-3-azatricyclo[7.3.1.0, ]trideca-1(13), 5, 7, 9, 11-pentaen-3-yl}hexanamido)phenyl]arsonous acid

Smiles: NC1=CC=C2C3C1=CC=CC=3C(=O)N(CCCCCC(=O)NC1C=CC(=CC=1)[As](O)O)C2=O

InChiKey: CVWSXPBPPSJPCI-UHFFFAOYSA-N

InChi: InChI=1S/C24H24AsN3O5/c26-20-13-12-19-22-17(20)5-4-6-18(22)23(30)28(24(19)31)14-3-1-2-7-21(29)27-16-10-8-15(9-11-16)25(32)33/h4-6,8-13,32-33H,1-3,7,14,26H2,(H,27,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h).

References:

1. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.

Products are for research use only. Not for human use.