7 8-Dihydroneopterin

7, 8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7, 8-Dihydroneopterin can be used in the research of neurodegenerative diseases.

Product information

CAS Number: 1218-98-0

Molecular Weight: 255.23

Formula: C9H13N5O4

Chemical Name: 2-amino-6-[(1S, 2R)-1, 2, 3-trihydroxypropyl]-3, 4, 7, 8-tetrahydropteridin-4-one

Smiles: NC1NC(=O)C2N=C(CNC=2N=1)[C@H](O)[C@H](O)CO

InChiKey: YQIFAMYNGGOTFB-XINAWCOVSA-N

InChi: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

7, 8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y). 7, 8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes.

References:

1. C Speth, et al. Inflammation Marker 7,8-dihydroneopterin Induces Apoptosis of Neurons and Glial Cells: A Potential Contribution to Neurodegenerative Processes. Immunobiology. 2000 Nov;202(5):460-76.

Products are for research use only. Not for human use.