Catalog No. Size 价格库存数量
S0740-2 2mg solid ¥135
S0740-10 10mg solid ¥405


L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.

Product information

CAS Number: 56-88-2

Molecular Weight: 222.26

Formula: C7H14N2O4S

Chemical Name: (2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid

Smiles: N[C@@H](CSCC[C@H](N)C(O)=O)C(O)=O


InChi: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 25 mg/mL (112.48 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 80°C) DMSO : 1 mg/mL (4.50 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Homocysteine obviously induces the apoptosis of HUVECs, and this effect is significantly attenuated by the pretreatment with L-cystathionine. Furthermore, L-cystathionine decreases the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increases mitochondrial membrane potential, inhibits mitochondrial permeability transition pore (MPTP) opening, suppresses the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3. L-Cystathionine is an important metabolic intermediate in the L-cysteine transsulfuration pathway from L-methionine via L-homocysteine in mammalian tissues.


  1. Xiuli Wang, et al. L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells. Oxid Med Cell Longev. 2019 Nov 25;2019:1253289.
  2. Amino Y, et al. Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis. Biosci Biotechnol Biochem. 2017 Jan;81(1):95-101.

Products are for research use only. Not for human use.


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