MK2-IN-3 hydrate

MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2.

Product information

CAS Number: 1186648-22-5

Molecular Weight: 358.39

Formula: C21H18N4O2

Chemical Name: 2-[2-(quinolin-3-yl)pyridin-4-yl]-1H, 4H, 5H, 6H, 7H-pyrrolo[3, 2-c]pyridin-4-one hydrate

Smiles: O.O=C1NCCC2NC(=CC=21)C1=CC(=NC=C1)C1=CC2=CC=CC=C2N=C1

InChiKey: NIKCVKMHGQQSRN-UHFFFAOYSA-N

InChi: InChI=1S/C21H16N4O.H2O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15;/h1-5,7,9-12,25H,6,8H2,(H,23,26);1H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC50 of 4.4 μM.

References:

1. Anderson DR, et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.

Products are for research use only. Not for human use.