Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers.

Product information

CAS Number: 871307-18-5

Molecular Weight: 404.83

Formula: C21H14ClFN6

Chemical Name: 4-[(3-chloro-4-fluorophenyl)amino]-6-{[(pyridin-3-yl)methyl]amino}-1, 7-naphthyridine-3-carbonitrile

Smiles: N#CC1=CN=C2C=NC(=CC2=C1NC1C=C(Cl)C(F)=CC=1)NCC1=CC=CN=C1

InChiKey: NMEUKWOOQOHUNA-UHFFFAOYSA-N

InChi: InChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.

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