Catalog No. Size 价格库存数量
S0876-2 2mg solid ¥95
S0876-10 10mg solid ¥285


NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM.

Product information

CAS Number: 113104-25-9

Molecular Weight: 290.25

Formula: C11H6N4O4S

Chemical Name: 2-[(7-nitro-2, 1, 3-benzoxadiazol-4-yl)sulfanyl]pyridin-1-ium-1-olate

Smiles: [O-][N+]1=CC=CC=C1SC1=CC=C(C2=NON=C12)[N+]([O-])=O


InChi: InChI=1S/C11H6N4O4S/c16-14-6-2-1-3-9(14)20-8-5-4-7(15(17)18)10-11(8)13-19-12-10/h1-6H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 16 mg/mL (55.12 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NSC 228155 (100 μM) enhances EGFR tyrosine phosphorylation via action of SOD1. NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with IC50s of 2.09 and 6.14 μM, respectively. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells.


  1. Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088.
  2. Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.

Products are for research use only. Not for human use.


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