详情描述
Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC).
Product information
CAS Number: 236102-87-7
Molecular Weight: 448.47
Formula: C25H24N2O6
Chemical Name: (1S)-1-(hydroxymethyl)-3-(5, 6, 7-trimethoxy-1H-indole-2-carbonyl)-1H, 2H, 3H-benzo[e]indol-5-ol
Smiles: COC1=C(OC)C2NC(=CC=2C=C1OC)C(=O)N1C[C@@H](CO)C2=C1C=C(O)C1=CC=CC=C21
InChiKey: ITTCPQPHJURTKF-AWEZNQCLSA-N
InChi: InChI=1S/C25H24N2O6/c1-31-20-9-13-8-17(26-22(13)24(33-3)23(20)32-2)25(30)27-11-14(12-28)21-16-7-5-4-6-15(16)19(29)10-18(21)27/h4-10,14,26,28-29H,11-12H2,1-3H3/t14-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Gieseg MA, et al. Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA. Anticancer Drug Des. 1999 Feb;14(1):77-84.
Products are for research use only. Not for human use.