Eupalinolide K

Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .

Product information

CAS Number: 108657-10-9

Molecular Weight: 362.42

Formula: C20H26O6

Chemical Name: (3aR, 4R, 9S, 11aR)-9-hydroxy-6, 10-dimethyl-3-methylidene-2-oxo-2H, 3H, 3aH, 4H, 5H, 8H, 9H, 11aH-cyclodeca[b]furan-4-yl (2E)-4-hydroxy-2-methylbut-2-enoate

Smiles: C/C(=C\CO)/C(=O)O[C@@H]1CC(C)=CC[C@H](O)C(C)=C[C@H]2OC(=O)C(=C)[C@@H]21 |c:11,17|

InChiKey: APOGLVUGPAVNAP-NMSLRBGTSA-N

InChi: InChI=1S/C20H26O6/c1-11-5-6-15(22)13(3)10-17-18(14(4)20(24)26-17)16(9-11)25-19(23)12(2)7-8-21/h5,7,10,15-18,21-22H,4,6,8-9H2,1-3H3/b11-5-,12-7+,13-10-/t15-,16+,17+,18+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Yang B, , et al. Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer. Nat Prod Res. 2019 Feb;33(4):477-485.

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