Angoline hydrochloride

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Catalog No. Size 价格库存数量
S0955-2 2mg solid ¥230
售罄
不可用
S0955-10 10mg solid ¥845
售罄
不可用

详情描述

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

Product information

CAS Number: 1071676-04-4

Molecular Weight: 415.87

Formula: C22H22ClNO5

Chemical Name: 17, 18, 20-trimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.8.0.0, .0, .0, ]henicosa-1(13), 2, 4(8), 9, 11, 14(19), 15, 17-octaene hydrochloride

Smiles: Cl.CN1C(OC)C2=C(OC)C(=CC=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC

InChiKey: IHTYZEWKBYYBBI-UHFFFAOYSA-N

InChi: InChI=1S/C22H21NO5.ClH/c1-23-20-14(6-5-12-9-17-18(10-15(12)20)28-11-27-17)13-7-8-16(24-2)21(25-3)19(13)22(23)26-4;/h5-10,22H,11H2,1-4H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

Products are for research use only. Not for human use.

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