详情描述
KT5720 is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM.
Product information
CAS Number: 108068-98-0
Molecular Weight: 537.61
Formula: C32H31N3O5
Chemical Name: hexyl (15R, 16S, 18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4, 14, 19-triazaoctacyclo[12.11.2.1, .0, .0, .0, .0, .0, ]octacosa-1(26), 2(6), 7(27), 8, 10, 12, 20(25), 21, 23-nonaene-16-carboxylate
Smiles: C[C@@]12O[C@@H](C[C@@]1(O)C(=O)OCCCCCC)N1C3C4=C(C5=CC=CC=C5N24)C2CNC(=O)C=2C=3C2C=CC=CC1=2
InChiKey: ZHEHVZXPFVXKEY-RUAOOFDTSA-N
InChi: InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Methanol : 5 mg/mL (9.30 mM; Need ultrasonic and warming)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
- Murray A, et al. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal. 2008 Jun 3;1(22):re4.
Products are for research use only. Not for human use.