Catalog No. Size 价格库存数量
S1114-2 2mg solid ¥105
S1114-10 10mg solid ¥315


NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.

Product information

CAS Number: 2342583-66-6

Molecular Weight: 447.50

Formula: C22H28F3N7

Chemical Name: 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-{[3-(trifluoromethyl)phenyl]methyl}-9H-purine-2, 6-diamine

Smiles: CN(C)CCNC1=NC(NCC2=CC=CC(=C2)C(F)(F)F)=C2N=CN(C(C)C3CC3)C2=N1


InChi: InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (279.33 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.


  1. Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998.

Products are for research use only. Not for human use.


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