NCC007

NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.

Product information

CAS Number: 2342583-66-6

Molecular Weight: 447.50

Formula: C22H28F3N7

Chemical Name: 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-{[3-(trifluoromethyl)phenyl]methyl}-9H-purine-2, 6-diamine

Smiles: CN(C)CCNC1=NC(NCC2=CC=CC(=C2)C(F)(F)F)=C2N=CN(C(C)C3CC3)C2=N1

InChiKey: GHRNSZVMIARHIS-UHFFFAOYSA-N

InChi: InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (279.33 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.

References:

1. Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998.

Products are for research use only. Not for human use.