Hydroxy-PEG1-(CH2)2-Boc

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Catalog No. Size 价格库存数量
S1169-2 2mg solid ¥80
售罄
不可用
S1169-10 10mg solid ¥240
售罄
不可用

详情描述

Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 671802-00-9

Molecular Weight: 190.24

Formula: C9H18O4

Chemical Name: tert-butyl 3-(2-hydroxyethoxy)propanoate

Smiles: CC(C)(C)OC(=O)CCOCCO

InChiKey: ACWLDITVZGWIKA-UHFFFAOYSA-N

InChi: InChI=1S/C9H18O4/c1-9(2,3)13-8(11)4-6-12-7-5-10/h10H,4-7H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 100 mg/mL (525.65 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Products are for research use only. Not for human use.

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