Glutarimide-Isoindolinone-NH-PEG2-COOH

Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.

Product information

Molecular Weight: 419.43

Formula: C20H25N3O7

Chemical Name: 3-[2-(2-{[2-(2, 6-dioxopiperidin-3-yl)-1-oxo-2, 3-dihydro-1H-isoindol-5-yl]amino}ethoxy)ethoxy]propanoic acid

Smiles: OC(=O)CCOCCOCCNC1=CC2CN(C3CCC(=O)NC3=O)C(=O)C=2C=C1

InChiKey: OLXWGGOWRQJBRT-UHFFFAOYSA-N

InChi: InChI=1S/C20H25N3O7/c24-17-4-3-16(19(27)22-17)23-12-13-11-14(1-2-15(13)20(23)28)21-6-8-30-10-9-29-7-5-18(25)26/h1-2,11,16,21H,3-10,12H2,(H,25,26)(H,22,24,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
2. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.

Products are for research use only. Not for human use.