KB02-COOH

KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610).

Product information

CAS Number: 2375196-30-6

Molecular Weight: 283.71

Formula: C13H14ClNO4

Chemical Name: 2-{[1-(2-chloroacetyl)-1, 2, 3, 4-tetrahydroquinolin-6-yl]oxy}acetic acid

Smiles: OC(=O)COC1=CC2CCCN(C=2C=C1)C(=O)CCl

InChiKey: ZWIYQLVGARZWJJ-UHFFFAOYSA-N

InChi: InChI=1S/C13H14ClNO4/c14-7-12(16)15-5-1-2-9-6-10(3-4-11(9)15)19-8-13(17)18/h3-4,6H,1-2,5,7-8H2,(H,17,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 66.67 mg/mL (234.99 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

Products are for research use only. Not for human use.