SMCy 5.5

SMCy 5.5 is a fluorogenic fluorescent probe for imaging lipid droplets that exhibits sharp excitation and emission bands and high brightness. SMCy 5.5 is suitable for use with two-photon microscopy. It is useful for deep tissue imaging and 3D imaging. Excitation/emission maxima for SMCy 5.5 in THF are 643/672 nm; Quantum yield = 0.75; Extinction coefficient = 209, 000 M-1 cm-1. SMCy 5.5 displays high two-photon absoprtion (TPA) cross-section values (13330 GM and 10400 GM at 770 and 820 nm, respectively). The probe also has a click reactive handle.

Product information

CAS Number: 2417507-09-4

Molecular Weight: 693.63

Formula: C41H46BF2N3O4

Chemical Name: 6, 8-Dicyclohexyl-4-((1E, 3E, 5E)-5-(1, 1-dimethyl-3-(pent-4-yn-1-yl)-1, 3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1, 3-dien-1-yl)-2, 2-difluoro-2, 8-dihydro-5H-13, 24-[1, 3, 2]dioxaborinino[6, 5-d]pyrimidine-5, 7(6H)-dione

Smiles: CC1(C)/C(=C\C=C\C=C\C2O[B-](F)(F)[O+]=C3C=2C(=O)N(C2CCCCC2)C(=O)N3C2CCCCC2)/N(CCCC#C)C2=CC=C3C=CC=CC3=C12

InChiKey: CCEAGIQCUXUBGY-GNVKXZRTSA-N

InChi: InChI=1S/C41H46BF2N3O4/c1-4-5-17-28-45-33-27-26-29-18-15-16-23-32(29)37(33)41(2,3)35(45)25-14-8-13-24-34-36-38(48)46(30-19-9-6-10-20-30)40(49)47(31-21-11-7-12-22-31)39(36)51-42(43,44)50-34/h1,8,13-16,18,23-27,30-31H,5-7,9-12,17,19-22,28H2,2-3H3/b14-8+,24-13+,35-25+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Fam et al (2018) Recent advances in fluorescent probes for lipid droplets. Materials (Basel) 11 1768 PMID: 30231571
2. Collot et al (2018) Ultrabright and fluorogenic probes for multicolor imaging and tracking of lipid droplets in cells and tissues. J.Am.Chem.Soc. 140 5401 PMID: 29446627

Products are for research use only. Not for human use.